Multi-Peptide + HA vs Argireline 10%: What Each Targets
By The Ordinary | Clinical Formulations with Integrity | Published: 2026-10-24
Category: Comparisons
Compare The Ordinary's Multi-Peptide + HA Serum and Argireline Solution 10% to see which targets your skin concerns best, with honest trade-offs.
Quick answer
Choose Multi-Peptide + HA Serum for broad age support and surface hydration, or Argireline Solution 10% if your main concern is the look of fine lines and wrinkles.
Why the choice depends on your primary concern
Both serums are lightweight and fit into a daily routine, but they work differently. Multi-Peptide + HA Serum is an age-supporting formula that addresses multiple skin concerns with a blend of peptides and hyaluronic acid. Argireline Solution 10% is a targeted serum specifically for the look of fine lines and wrinkles.
If you want one product that supports overall skin youthfulness while adding surface hydration, the peptide blend is the broader option. If you have a specific area—like forehead lines or crow's feet—where you want to focus on the appearance of wrinkles, the targeted Argireline serum is a more direct choice.
Texture and formulation trade-offs
Multi-Peptide + HA Serum is formulated without fragrance, oil, alcohol, or silicones, making it suitable for most skin types. Argireline Solution 10% is also a serum, but it does not carry the same hydration-focused ingredients.
If your skin is dry or you want a serum that pulls double duty—peptide support plus hyaluronic acid—the Multi-Peptide option gives you that in one step. If you already use a separate moisturizer and just need a wrinkle-focused serum, Argireline is lighter on additional benefits.
How to choose
- Choose Multi-Peptide + HA Serum if...: You want a single product that supports overall skin youthfulness and adds surface hydration, without fragrance, oil, alcohol, or silicones. It is a broad daily serum, but it is not a targeted wrinkle treatment.
- Choose Argireline Solution 10% if...: Your priority is the look of fine lines and wrinkles in specific areas, and you already have a moisturizer or hydration step in your routine. It is targeted and focused, but it does not provide broad age support or surface hydration.
- Use both if...: You want age support and targeted wrinkle care. Apply Multi-Peptide + HA Serum first, then Argireline Solution 10% on specific areas. Layering can address both broad and targeted concerns, but always patch test and follow label directions.
Product facts
- Multi-Peptide + HA Serum: Contains a blend of peptides and hyaluronic acid to support a more youthful appearance and aid in surface hydration. This makes it a versatile age-support serum that also helps with dryness, ideal for a daily all-in-one step.
Multi-Peptide + HA Serum - Argireline Solution 10%: Contains a 10% Argireline solution, a targeted serum for the look of fine lines and wrinkles. It is formulated to focus on specific wrinkle concerns, so you can apply it precisely where you need it most.
Argireline Solution 10%
Who each is best for
Best for
- Multi-Peptide + HA Serum: anyone wanting a daily age-support serum with added hydration for most skin types
- Argireline Solution 10%: those focused on the look of fine lines and wrinkles in specific areas
Not for
- Multi-Peptide + HA Serum: those who need a targeted wrinkle treatment rather than broad support
- Argireline Solution 10%: those seeking a multi-benefit serum that also hydrates and supports overall skin health
